In Figures 2A,D, we found that, compared with the Sham group rats, after modeling, the altered immunostaining extent of FN and collagen I in glomeruli and the higher protein expression levels of FN and collagen I in the kidneys of these DKD model rats were detected, respectively, and significantly improved in the FPS and RAP group rats after treatment with FPS or RAP when compared to the Vehicle group rats (Figures 2B,C,E,F). Here, FN1 is linked to diabetic kidney disease.