In Figures 4C, 5A, 6A, we found that, compared with the Sham group rats, after modeling, the changed immunostaining extent of podocin and CD2AP in glomeruli, and the altered protein expression levels of podocin, CD2AP, neph1, IL-6, and TLR4 in the kidneys of these DKD model rats were detected, respectively, and significantly improved in the FPS and RAP group rats after treatment with FPS or RAP when compared to the Vehicle group rats. This evidence concerns the gene KIRREL1 and diabetic kidney disease.