Zhang et al. (2017) found that autophagy can downregulate NLRP3 inflammasome via mammalian target of rapamycin (mTOR) signaling. Accordingly, Yang et al. (2019) reported that NLRP3 inflammasome can be inhibited by metformin and rapamycin (RAP, an mTOR inhibitor) by targeting the adenosine monophosphate-activated protein kinase (AMPK)/mTOR complex 1 (mTORC1)-dependent effects in diabetic cardiomyopathy. This evidence concerns the gene NLRP3 and diabetic cardiomyopathy.