CASP1 and diabetic kidney disease: In this study, IHC staining and WB analysis showed that the increased immunostaining of NLRP3, ASC, and Caspase-1 in glomeruli and the higher protein expression levels of NLRP3, ASC, and cleaved-Caspase-1 in the kidneys of the DKD model rats were significantly decreased after treatment with FPS or RAP.