Study have demonstrated that during the inflammatory process of ARDS, the synergism of TNF-α and IFN-γ could trigger inflammatory cell death, including pyroptosis and apoptosis, which involved multiple signal transduction pathways such as NLRP3/caspase, and JAK/STAT signaling pathways (Karki et al., 2021). The gene discussed is IFNG; the disease is acute respiratory distress syndrome.