Very recently, Manigrasso et al. developed a small molecule inhibitor of RAGE, RAGE229, which attenuated the complications of diabetes-associated kidney disease in mouse models by inhibiting the interactions between the cytoplasmic tail of RAGE and Diaphanous-1, thus completely inhibiting the intracellular RAGE signaling (Manigrasso et al., 2021). This evidence concerns the gene AGER and diabetes mellitus.