Alzheimer’s disease (AD) is a complex, aging-related, neurodegenerative disease, and the pathology process mainly involves β-amyloid (Aβ) overproduction and accumulation, tau hyperphosphorylation, and neuronal loss (Lian et al., 2016; Spangenberg et al., 2016; Gao et al., 2018). This evidence concerns the gene MAPT and Alzheimer disease.