MOG and in situ carcinoma: Kortvelyessy et al. (2017) reported two adult patients presenting with intracranial perivascular microlesions that were eventually found to be MOG-IgG positive. Brilot’s results showed that 40% of children with clinically isolated syndrome (CIS) or ADEM were positive for MOG-IgG (Brilot et al., 2009). Hennes et al. (2017) found that 57% of children with ADEM were positive for MOG-IgG. Lopez-Chiriboga’s results showed that 25 of 51 patients (49%) with onset-isolated ADEM were positive for MOG-IgG (Lopez-Chiriboga et al., 2018).