TNFRSF1A and Stroke: Furthermore, at the molecular level, R-7050 acts as an anti-TNF-α receptor inhibitor demonstrating protection against stroke-induced brain injury (King et al., 2013; Clausen et al., 2014; Arango-Dávila et al., 2015; Wu et al., 2016) as well as enhancing the brain TNFRI and NF-κB signaling cascades along with increased levels of the Nrf2 protein in stroke rats, suggesting that R-7050 may enhance Nrf2 signaling, thus representing the involvement of another signal transduction to alleviate inflammatory responses in IS (Lin et al., 2021).