Furthermore, at the molecular level, R-7050 acts as an anti-TNF-α receptor inhibitor demonstrating protection against stroke-induced brain injury (King et al., 2013; Clausen et al., 2014; Arango-Dávila et al., 2015; Wu et al., 2016) as well as enhancing the brain TNFRI and NF-κB signaling cascades along with increased levels of the Nrf2 protein in stroke rats, suggesting that R-7050 may enhance Nrf2 signaling, thus representing the involvement of another signal transduction to alleviate inflammatory responses in IS (Lin et al., 2021). This evidence concerns the gene NFKB1 and Stroke.