Compared with CN group, the percentage of APOE4-positive was significantly higher in AD group (12.3 vs. 38.3%, p < 0.0001), whereas BMI (23.86 ± 2.99 vs. 20.72 ± 2.19, p < 0.0001), TC (4.20 ± 0.86 vs. 3.76 ± 0.72, p = 0.001), TG (1.68 ± 0.54 vs. 1.24 ± 0.41, p < 0.0001), and HDL-C (1.33 ± 0.29 vs. 1.18 ± 0.24, p = 0.001) were markedly lower, respectively. Here, APOE is linked to Alzheimer disease.