In AD group, ApoM and all the derived indicators were significantly positively correlated with plasma p-tau217 (each p ≤ 0.01) and NfL (each p ≤ 0.001), but all the correlation coefficients were low (<0.5) except that of ApoM with NfL (rs = 0.507) (Figure 5). This evidence concerns the gene APOM and Alzheimer disease.