The AD research framework proposed by NIA-AA in 2018 categorized AD biomarkers into A/T(N) system (Jack et al., 2018), in which the core biomarkers were mainly based on cerebrospinal fluid (CSF) test [e.g., CSF-amyloid β (Aβ) and CSF-phosphorylated-tau (p-tau)] or positron emission tomography (PET) test (e.g., 11C-Pittsburgh compound B (PiB)-PET and tau-PET) (Jack et al., 2018). Here, MAPT is linked to Alzheimer disease.