When AD risk factors (age, sex, and APOE4 carriage status) and BMI were adjusted, the plasma ApoM level (OR = 1.058, 95% CI: 1.027–1.090, p < 0.0001) and the ratios of ApoM/TC (OR = 1.239, 95% CI: 1.120–1.372, p < 0.0001), ApoM/TG (OR = 1.064, 95% CI: 1.035–1.095, p < 0.0001), ApoM/HDL-C (OR = 1.069, 95% CI: 1.037–1.102, p < 0.0001), and ApoM/LDL-C (OR = 1.064, 95% CI: 1.023–1.106, p = 0.002) were significantly associated with the presence of AD, respectively (Table 2). Here, APOE is linked to Alzheimer disease.