Moreover, dysregulation of water homeostasis in the central nervous system (CNS) mediated by glial cells appear to play critical and interactive roles regarding the pathophysiology of neurovascular dysfunction of neurodegenerative diseases (NDs) and ischemia such as stroke, and targeting aquaporin 4 (AQP4) channels might be a potential therapeutic strategy (Kitchen et al., 2020; Sylvain et al., 2021). Here, AQP4 is linked to ischemia.