In this study, we generated three SNHL mouse models derived from aging, noise exposure, and cisplatin ototoxicity, constructed gene co-expression modules of the cochlear transcriptomes during creating SNHL models and systematically validated the crucial roles of NF-kappa B signaling pathway, Jak-STAT signaling pathway, TNF signaling pathway, and Oxidative phosphorylation in generating SNHL. Here, TNF is linked to sensorineural hearing loss disorder.