Besides IL1B and CCL2, several additional co-regulators were found to be involved in the SNHL-shared inflammatory and immune responses through TNF signaling pathway, NF-kappa B signaling pathway, and Jak-STAT signaling pathway, including TNFRSF1A, TRAF6, MYD88, AKT1, STAT3, EP300, and SOCS3 (Figure 3C). This evidence concerns the gene EP300 and sensorineural hearing loss disorder.