SCN1A and Dravet syndrome: While NaV1.1 channels were shown to be expressed in pyramidal excitatory neurons (Westenbroek et al., 1989; Yu et al., 2006; Cembrowski et al., 2016) and several studies demonstrated their structural and functional changes in DS (Mistry et al., 2014; Tsai et al., 2015; Salgueiro-Pereira et al., 2019; Almog et al., 2021), others reported unaltered excitability of these cells (Yu et al., 2006; Rubinstein et al., 2015b; De Stasi et al., 2016; Favero et al., 2018).