SCN1A and epilepsy: While haploinsufficiency in NaV1.1 activity results in Dravet, milder SCN1A mutations lead to less severe and treatable epilepsies, such as Generalized Epilepsy with Febrile Seizures Plus (GEFS+) and benign febrile seizures (Catterall et al., 2010; Nissenkorn et al., 2019).