Diabetes can amplify NLRP3 and caspase-1 activation in rats after ischemia (Ward et al., 2019), which can mediate the facilitation of tPA-induced BBB damage (Ismael et al., 2020, 2021; Chen et al., 2021a) and the tendency of HT in ischemic stroke (Ismael et al., 2020). The gene discussed is CASP1; the disease is ischemic stroke.