CASP1 and brain edema: Accumulating evidence have shown caspase-1 activation plays pivotal roles in exacerbating cerebral edema (Wu et al., 2010; Lin et al., 2018; Liang et al., 2019; Li et al., 2020b; Zhang et al., 2020) and increasing the occurrence of HT (Ismael et al., 2018; Chen et al., 2021a) via loosening BBB integrity (Liang et al., 2020).