CASP1 and ischemic stroke: Although various models have been developed for ischemic stroke, such as transient middle cerebral artery occlusion (MCAO; Li et al., 2019, 2020c), permanent MCAO (Dong et al., 2013; Liang et al., 2020), embolic MCAO (Ishrat et al., 2015), and photothrombotic stroke (Li et al., 2020b) etc., caspase-1 expression can be enhanced in the acute phase of all models above.