The reduction of AIM2 inflammasome and caspase-1 expression via cyclic GMP–AMP synthase antagonist A151 (Li et al., 2020c), NLRP6 reduction via NLRP6 siRNA (Meng et al., 2019), and restraining NLRC4 activation via RGS2 (Gan et al., 2021) all show the attenuation of cerebral edema. Here, CASP1 is linked to brain edema.