Meanwhile, since the effects share resembling characteristics in various patterns of ischemic and hemorrhagic stroke (Wu et al., 2010; Lin et al., 2018; Li et al., 2019, 2020b; Liang et al., 2019, 2020), caspase-1-dependent effects on BBB will be concerned with stroke events as a whole (Figure 2). Here, CASP1 is linked to hemorrhagic stroke.