Switch genes identified in the dataset GSE52946 were enriched in several pathways including, proteasome, legionellosis, PPAR signaling, antigen processing, and presentation, peroxisome, IL-17 signaling, prostate cancer, progesterone-mediated oocyte maturation, Th17 cell differentiation, and oxidative phosphorylation. The gene discussed is PPARA; the disease is prostate cancer.