PLEKHM1 and amyotrophic lateral sclerosis: Initial analysis of one isoform of each gene of interest using the NYGC ALS cohort demonstrated that SVA_67 allele dosage is significantly associated with differential expression of the specific isoforms MAPT-208, KANSL1-214, LRRC37A-202, CRHR1-205, PLEKHM1-212 and ARL17A-203 (Figure 2).