Although GSK3β is directly regulated by Skp2, here we determined whether the activity of GSK3β can influence the expression of RIP1, SB216763 was used to inhibit the activation of GSK3β in AML cell lines to validate whether Skp2 regulates RIP1 through the level of p-GSK3β. The gene discussed is SKP2; the disease is acute myeloid leukemia.