Raw counts of RNA-sequencing data of Skp2 and RIP1 were obtained from Therapeutically Applicable Research To Generate Effective Treatments (TARGET) dataset (https://ocg.cancer.gov/programs/target), Spearman correlation analysis of Skp2 gene expression and RIP1 expression was performed and the data shown that the positive correlation was presented between the two gene in AML (Fig. 1C). Here, RIPK1 is linked to acute myeloid leukemia.