It is assumed that the transcriptional regulation of HOXA5 might be involved in the critical deacetylaton of p53 by SIRT1 in LUAD and non-small cell lung cancer, and that the marked down-regulation of HOXA4 and HOXA5 in LUAD may be linked to transcriptional dysregulation of SIRT1 which is now strongly linked to LUAD and non-small lung cancer. Here, TP53 is linked to non-small cell lung carcinoma.