Heidi et al. uncovered the frequent dysregulation of HOXA family genes including HOXA2, HOXA3, HOXA4, HOXA7, HOXA9, HOXA10 and HOXA11 in multiple myeloma, a disease featured by malignant growth of plasma cells in the bone marrow 27. The gene discussed is HOXA10; the disease is plasma cell myeloma.