HOXA4 and neoplasm: With respect to the relationships between functional states of LUAD cells and HOXA4 or HOXA5 expression, significant gene-state pairs of HOXA4-stemness and HOXA5-hypoxia suggested that HOXA4 and HOXA5 might block the development of LUAD through decreasing stemness of LUAD cells or increasing the hypoxia level of tumor microenvironment.