Patients with AL-MM had the same incidence of Alb < 25 g/L, 24-h UTP > 3.5 g, ALP ≥ 187.5IU/L, GGT ≥ 85 IU/L, TBIL ≥ 20 μmol/L, BNP ≥ 1500 pg/mL, EF < 50%, and BU staging system stage ≥ III, which represented AL amyloidosis severity. This evidence concerns the gene NPPB and AL amyloidosis.