PMAIP1 and neoplasm: To assess the effect of NOXA expression in tumor cells on the antitumor efficacy of CAR T cells in vivo, we engrafted NOD-Prkdcscid Il2rgnull (NPG) mice with sgCONT or NOXAKO Nalm6 via tail vein, and then infused control T cells or CD19 CAR T cells intravenously (Fig. 4a).