Other real-world implementations of KMSubtraction were demonstrated to yield similar if not identical treatment effects in KEYNOTE-590 [23] among patients with advanced gastroesophageal adenocarcinoma dichotomized by CPS and in CheckMate-227 [24] among patients with advanced non-small cell lung cancer dichotomized by PD-L1 expression levels [10]. Here, CD274 is linked to non-small cell lung carcinoma.