In addition, according to Zhai et al. [41], konjac-glucomannan combined with bacterial cellulose exerted a better effect on liver inflammation due to obesity by lowering the levels of TNF and IL-6 and reducing the protein expression of nuclear factor erythroid 2-related factor 2 compared with mice that were only given additional bacterial cellulose or konjac-glucomannan alone. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.