NLRP3 and colon adenocarcinoma: Although previous studies have reported that C. albicans can inhibit NLRP3 and NLRP6 expression in Caco-2 cells (Mao et al., 2020), it is important to note that since the Caco-2 cell line is derived from a human colon adenocarcinoma cell line, it could not fully reflect the real response to abnormal colonization by C. albicans.