ART4 and COVID-19: S glycoprotein is a great inducer of neutralizing antibodies and encompasses multiple epitopes, making it an important target and informative source for CoVs vaccine design (Du et al., 2009), including the licensed vaccines against SARS-CoV-1 (Du et al., 2009) and the SARS-CoV-2 vaccines used to fight against the ongoing COVID-19 pandemic (Samrat et al., 2020; Dai and Gao, 2021).