CD4 and infection: Moreover, the proportion of infiltration of CD4+ and CD8+ T lymphocytes in saline, vaccine (Reo-2,177®), Clodronate liposome + Reo-V3 or cyclosporine + Reo-V3 groups were significantly lower (p < 0.0001) as compared to Reo-V3 group at day 9 post-infection (Figure 10B).