C12orf75 and coronary artery disorder: As shown in Figure 4A and Supplementary Figure 1, ROC analysis demonstrated favorable diagnostic efficacy of the above three biomarkers in discriminating MI from CAD samples with an AUC of 0.807 (95% CI 0.732–0.883) for SYTL2, 0.843 (95% CI 0.776–0.909) for KLRD1, and 0.829 (95% CI 0.758–0.901) for C12orf75.