NT-proBNP gradually decreased from heart failure with reduced ejection fraction (HFrEF), heart failure with mid-range ejection fraction (HFmrEF) to heart failure with preserved ejection fraction (HFpEF) (p = 0.002 for trend) (Figure 2E), but FGF21 did not (p = 0.843 for trend) (Figure 2D), in HFrEF, HFmrEF and HFpEF patients. The gene discussed is FGF21; the disease is heart failure.