Gene Set Enrichment Analysis (GSEA) showed an enrichment of pathways associated with inflammation and liver fibrosis in SuHx animals, in particular TNFα signaling, IL6-JAK-STAT3 signaling, Interferon alpha (IFNα) and gamma (IFNγ) response (Figures 5A,B). This evidence concerns the gene STAT3 and Hepatic fibrosis.