Importantly, a total of seven out of 12 significantly enriched signaling pathways were evident in both SuHx rats and patients with congestive hepatopathy: The enriched pathways included proinflammatory pathways such as tumor necrosis factor alpha and interferon alpha and gamma signaling and a hepatic stellate cell gene signature (42), indicating that HSC are the fibrogenic cell type responsible for the development of liver fibrosis in hepatic congestion in rats and human. The gene discussed is TNF; the disease is Hepatic fibrosis.