TP53 and diabetic cardiomyopathy: Furthermore, overexpression of SIRT3 has been shown to attenuate diabetic cardiomyopathy by deacetylating the transcription factor p53 and significantly reducing the expression of its downstream element, a fructose 2,6 bisphosphatase called TP53-induced glycolysis and apoptosis regulator (TIGAR) (47).