AGT and cardiac hypertrophy: Indeed, Muller et al. (31) observed a reduction of collagen production and LV hypertrophy in a model of angiotensin II induced organ damage in rats pretreated with 600 mg of aspirin, reporting that high ASA doses decreased mortality, cardiac hypertrophy, fibrosis, and albuminuria independently of blood pressure, by inhibition of IKK/NF-κB pathway.