As we found in patients with DM, we observed the same reduced mean intensity of Cx43 (Figure 4B), colocalization in Cx43 and N-cadherin (Figure 4C), and significant increase in Cx43 and Tomm20 colocalization (Figure 4D) in DCM mice, while acute hypoglycemia challenge can further intensify Cx43 translocation. This evidence concerns the gene CDH2 and diabetes mellitus.