GJA1 and familial dilated cardiomyopathy: As we found in patients with DM, we observed the same reduced mean intensity of Cx43 (Figure 4B), colocalization in Cx43 and N-cadherin (Figure 4C), and significant increase in Cx43 and Tomm20 colocalization (Figure 4D) in DCM mice, while acute hypoglycemia challenge can further intensify Cx43 translocation.