CREB1 and irritable bowel syndrome: Yu et al. utilized the CACS-induced IBS-like symptoms in male Sprague-Dawley (SD) rats, resveratrol treatment improves anti-IBS-like effects on depression, anxiety, visceral hypersensitivity, and intestinal motility abnormality through regulating 5-HT1A-dependent PKA-CREB-BDNF signaling in the gut-brain axis (96).