In this study, we have investigated 4 common SNPs (DRD2/ANKK1-rs1800497; DRD2-rs6277; DRD4-rs936461; DRD4-rs1800955), one TR (DRD4-120bp TR), and one VNTR (DRD4-48 bp VNTR) and their possible association with EDs in a large cohort of Italian patients. The gene discussed is DRD2; the disease is Ehlers-Danlos syndrome.