ANKK1 and X-linked cone dysfunction syndrome with myopia: Moreover, the A-allele (also called A1/A1 or A1/A2 genotype) of rs1800497 SNP, in the ANKK1 gene, has been associated with a reduction of D2/D3 receptors expression and activity (33, 40) and it was significantly more frequent in the obese group than in lean controls (36), contrarily to patients with BED that showed a higher proportion of homozygotes GG (A2-allele) (34).