In human colon cancer cells 6-shogaol is able to increase intracellular glutathione/glutathione disulfide ratio (GSH/GSSG), upregulating the expression of Nrf2, metallothionein 1 (MT1), heme oxygenase-1 (HO-1), ferritin light chain (FTL), aldo-keto reductase family 1 member B10 (AKR1B10), and γ-glutamyltransferase-like 4 activities (GGTLA4). Here, HMOX1 is linked to malignant colon neoplasm.