NOTCH1 and neoplasm: We then selected some genes related to CAC, such as VEGFA, BRAF, Notch1, PIK3CA, NTRK1, PTEN, and EGFR. The clustering results showed that the expression patterns of tumor-related genes in the BD5115 group were more similar to that in the normal group without treatment than in the CAC group (Figure 6E).