Patients with high nutritional risk measured by any of the three nutritional indices had lower BMI, ALB, Lymphocyte, Hb, TC, TG, HDL-C, and LDL-C, longer diabetes duration, higher prevalence of severe DFUs, lower GNRI and PNI, higher CONUT than those with low nutritional risk. The gene discussed is GSTM1; the disease is diabetes mellitus.