As a commonly used nonbiological artificial liver treatment in clinical practice in China, plasma exchange (PE) uses a membrane plasma separator to separate plasma from whole blood and then replenish the same amount of fresh frozen plasma, which can nonspecifically eliminate liver failure toxins and at the same time supplement essential substances lacking in the patient's body, such as albumin (ALB) and coagulation factors, so as to replace certain functions of the liver [9]. This evidence concerns the gene ALB and liver failure.