PECAM1 and neoplasm: Being capable of only limited self-care, the patient was precluded from chemotherapy; CD31 and CD34 immunostaining in the biopsy sample showed abundant microvessels in the tumor, indicating active tumor angiogenesis; thus, the patient was prescribed apatinib (250 mg) orally once per day; the prescription relieved chest stiffness and eradicated hemoptysis 5 days after treatment [70].