MSH2 and cancer: Our study is the first attempt to conduct a pan-cancer analysis on MSH2 by using databases of The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Cancer Cell Line Encyclopedia (CCLE), and others integratedly with relevant factors including gene expression, survival status, genetic alterations, immune infiltration, and associated cellular pathways, and we eventually elucidated MSH2's role in the pathogenesis or the prognosis of cancers.