Significant tumors (ACC, CESC, KIRP, LIHC, LUSC, PAAD and ACC, CESC, KICH, KIRC, KIRP, LGG, LIHC, PAAD, and UCEC) were selected in DFI and PFI survival analysis, and cancer cases were divided into high- and low-expression groups according to MSH2 expression levels for prognostic KM curves. The gene discussed is MSH2; the disease is cancer.