GRN and neoplasm: PCDGF is involved in tumor cell adhesion, cell proliferation, angiogenesis, and extracellular matrix degradation through stimulation of mitogen-activated protein kinase signaling pathway, phosphatidylinositol 3-kinase signaling pathway, and local adhesion kinase signaling pathway to promote tumor cell infiltration and metastasis, where its high expression levels are associated with tumor development [23].