Literature reported that the pretreatment of PEITC promoted the sensitivity of temozolomide- (TMZ-) resistant glioblastoma cell lines and toward TMZ to inhibit the expression of O6-methyl-guanine-DNA methyltransferase (MGMT) through suppressing NF-κB activity to reverse the chemoresistance [16]. The gene discussed is NFKB1; the disease is glioblastoma.