BRU (methyl (1R,2S,3R,6R,8R,13S,14R,15R,16S,17S)-10,15,16-trihydroxy-9,13-dimethyl-3-(3-methylbut-2-enoyloxy)-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate), the most potent and selective Nrf2 inhibitor, is a cytotoxic quassinoid natural extract from Brucea javanica and is frequently employed as a traditional Chinese herbal medicine for the treatment of amebiasis, cancer, and malaria [120–122]. This evidence concerns the gene NFE2L2 and cancer.