The results showed that in IGT individuals, obesity and metabolism-related indicators such as WHR, blood pressure (BP), triglyceride (TG), total cholesterol (TC), FFAs, HbA1c, FBG, 2-hour postglucose load blood glucose (2 h-BG), fasting insulin (FIns), 2-hour postglucose load blood insulin (2-Ins), area under the curve of glucose during oral glucose tolerance test (AUCg), and HOMA-IR were significantly increased, while serum ADIPOQ levels and HOMA-β were significantly decreased compared with NGT individuals (Table 1). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.