In the present study, we investigated circulating CTRP7 levels in individuals who were newly diagnosed with type 2 diabetes mellitus (T2DM) and prediabetes (IGT) and performed various intervention experiments to observe the effects of hyperglycemia, hyperinsulinemia, free fatty acid- (FFA-) induced IR, physical activity, and cold exposure on serum CTRP7 levels. This evidence concerns the gene C1QTNF7 and type 2 diabetes mellitus.