COG2 and cardiovascular disorder: In the Chinese Expert Consensus on the Diagnosis and Treatment of Coronary Microvascular Diseases, which was jointly promulgated by several academic teams including the Basic Research Group of the Chinese Society of Cardiovascular Diseases, it was pointed out [13] that atherosclerotic risk factors such as diabetes mellitus, hypertension, and high LDL-C level can be influenced by endothelium-dependent and non-endothelium-dependent mechanisms leading to abnormal microvascular function, manifested by reduced coronary flow reserve fraction and microvascular constriction.