In collagen II-induced arthritis male DBA/1J mice, ginkgolide B (10, 20, and 40 μM, i.p., for 43 days) decreased the serum levels of IL-1β, IL-6, TNF-α, MMP-3, and MMP-13 and increased the anti-inflammatory cytokine IL-10 [99]. This evidence concerns the gene TNF and arthritic joint disease.