Andrographolide when combined with methotrexate in complete Freund's adjuvant-induced arthritis in Wistar rats strengthened the antiarthritic capacity of methotrexate, reduced the inflammatory symptoms in animals, showed hepatoprotective activity, and significantly reduced serum TNF-α, IL-6, and IL-1β levels [76]. The gene discussed is IL6; the disease is arthritic joint disease.