MAPK14 and arthritic joint disease: Similarly, carnosic acid at 30 and 60 mg/kg (i.p., 4 weeks) in collagen-induced arthritis in male C57BL/KsJ-db/db mice and at 10 or 20 μM in mouse bone marrow cells reduced osteoclast formation and bone loss through suppression of inflammation by regulating the ROS-dependent p38 pathway [99].