Moreover, some other diterpenoids (rhodojaponin III, rhodojaponin VI, 2-O-methylrhodojaponin, and 5′-β-D-glucopyranosyloxyjasmonic acid) in Rhododendron molle fruits at 0.6 mg/kg dose dramatically reduced RA symptoms in CIA rats [68] by strongly preventing aberrant T and B lymphocyte proliferation and substantially decreased levels of the proinflammatory cytokines IL-1β and IL-6, as well as TNF-α. The gene discussed is TNF; the disease is rheumatoid arthritis.