Phlomisoside F (5, 10, and 20 mg/kg, p.o., for 28 days) inhibited the expression of TNF-α, IL-1β, IL-6, COX-2, and 5-lipoxygenase (5-LOX), and increased the expression of IL-10 in complete Freund's adjuvant-induced arthritis male Wistar rats [94]. This evidence concerns the gene TNF and arthritic joint disease.