11-epi-Sinulariolide acetate (9 mg/kg, s.c., once every 2 days from day 7 to day 28 postimmunization) reduced the expression of cathepsin K, MMP-9, TRAP, and TNF-α in ankle tissues in adjuvant-induced RA in female Lewis rats [89]. This evidence concerns the gene TNF and rheumatoid arthritis.