Accumulating data suggest the overexpression of PARP-1 in several cancer types, including malignant melanomas, neuroblastoma, colorectal cancer, breast cancer, HPV-positive oropharyngeal carcinoma, gastric cancer, testicular and germ cell tumors, malignant lymphoma, and Ewing's sarcoma [4–11]. This evidence concerns the gene PARP1 and cancer.