CRP and Decreased total leukocyte count: Egger's tests were performed to evaluate the publication bias of the studies on the primary outcomes of ACR20 (Egger's test: P = 0.513) and ACR50 (Egger's test: P = 0.539) and on the secondary outcomes of SJC (Egger's test: P = 0.555), TJC (Egger's test: P = 0.834), CRP (Egger's test: P = 0.217), ESR (Egger's test: P = 0.05), leukopenia (Egger's test: P = 0.250), and gastrointestinal adverse reaction (Egger's test: P = 0.844).