A significant correlation was observed between lower CD4 count and more prolonged HIV infection, older age, later stage of HIV infection, naïve treatment patients, seroconversion to anti-HCV antibody positive status, male gender, the symptom of gastrointestinal diseases, the emergence of RAMs, reduced adherence to previous ART regime(s), and being injection drug users (IDUs) (p < 0.05) (Fig. 1). This evidence concerns the gene CD4 and HIV infectious disease.