Although lncRNA ARAP1-AS2 has not been reported in RA, we assumed that ARAP1-AS2/miR-20b-3p/TRIM3 or ARAP1-AS2/miR-30c-3p/FRZB might be the key regulatory axes in the pathogenesis of RA based on the above analysis. The gene discussed is TRIM3; the disease is rheumatoid arthritis.