However, the luciferase reporter gene experiment showed that SOX11 did not activate the expression of MYCN, suggesting that SOX11 binds to sites other than the promoter region to directly or indirectly regulate the transcription of MYCN. These findings suggest that downregulation of miR-145-5p expression resulted in the increased expression of SOX11 and MYCN, promoting the NED and proliferation of PCa cells. The gene discussed is SOX11; the disease is posterior cortical atrophy.