Many studies aimed to evaluate the relationship between the IL-6 polymorphisms and allergic diseases risk in different populations (Reich et al., 2003; Settin et al., 2008; Trajkov et al., 2008; Xiaomin et al., 2008; Mahdaviani et al., 2009; Daneshmandi et al., 2012; Gharagozlou et al., 2013; Kosugi et al., 2013; Nasiri et al., 2014; Zhao et al., 2016; Babusikova et al., 2017). This evidence concerns the gene IL6 and allergic disease.