Additionally, XRCC1 rs1001581 genotypes (CC + CT) were associated with increased susceptibility to HIV-1 infection (dominant model: CC + CT vs TT: OR = 1.574, 95% CI = 1.146-2.163, p = 0.005; codominant model: CC vs TT: OR = 1.691, 95% CI = 1.193–2.397, p = 0.003; CT vs TT: OR = 1.496, 95% CI = 1.070–2.090, p = 0.018). This evidence concerns the gene XRCC1 and HIV-1 infection.