In the analysis of APEX1 rs1130409, genotype GG was associated with increased susceptibility to HIV-1 infection (recessive model: GG vs TT + TG: OR = 1.419, 95% CI = 1.056–1.907, p = 0.020; codominant model: GG vs TT: OR = 1.539, 95% CI = 1.100–2.152, p = 0.012). The gene discussed is APEX1; the disease is HIV-1 infection.