MAP2K5 and obesity due to melanocortin 4 receptor deficiency: Since then, a number of studies have pinpointed that MAP2K5 rs2241423 is associated with both childhood and adulthood obesity in different Asian populations and Caucasian, which most results were consistent (Speliotes et al., 2010; Dorajoo et al., 2012; Rask-Andersen et al., 2012; Wang et al., 2016; Lee et al., 2017).